High mutation load, immune-activated microenvironment, favorable outcome, and better immunotherapeutic efficacy in melanoma patients harboring <i>MUC16</i>/CA125 mutations

Qinghua Wang; Yichen Yang; Meng Yang; Xiangchun Li; Kexin Chen

doi:doi:10.18632/aging.103296

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Research Paper Volume 12, Issue 11 pp 10827—10843

High mutation load, immune-activated microenvironment, favorable outcome, and better immunotherapeutic efficacy in melanoma patients harboring MUC16/CA125 mutations

Figure 4. Correlation of MUC16 mutations with overall survival in 2 cohorts. (A, B) Kaplan-Meier survival analysis based on MUC16 mutational status (left: TCGA; right: ICGC). (C, D) Forest plot representation of association of MUC16 mutations with prognosis (left: TCGA; right: ICGC).