Figure 2. Subgroup analysis to evaluate the association between common irAEs and survival. Shown are the PFS and OS curves for patients with or without (A) skin irAEs, (B) endocrine irAEs, (C) hepatobiliary irAEs, (D) gastrointestinal irAEs, and (E) fatigue. The PFS and OS were significantly associated with skin, endocrine, and fatigue irAEs (P < 0.05).