Epigenome-wide gene–age interaction analysis reveals reversed effects of <i>PRODH</i> DNA methylation on survival between young and elderly early-stage NSCLC patients

Chao Chen; Yongyue Wei; Liangmin Wei; Jiajin Chen; Xin Chen; Xuesi Dong; Jieyu He; Lijuan Lin; Ying Zhu; Hui Huang; Dongfang You; Linjing Lai; Sipeng Shen; Weiwei Duan; Li Su; Andrea Shafer; Thomas Fleischer; Maria Moksnes Bjaanæs; Anna Karlsson; Maria Planck; Rui Wang; Johan Staaf; Åslaug Helland; Manel Esteller; Ruyang Zhang; Feng Chen; David C. Christiani

doi:doi:10.18632/aging.103284

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Research Paper Volume 12, Issue 11 pp 10642—10662

Epigenome-wide gene–age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients

Figure 2. DNA methylation and age interaction on survival of lung adenocarcinoma (LUAD) patients. (A) Hazard ratio (HR) of cg14326354_PRODH 5% per decrement of methylation level among different aged patients. The 95% confidence interval (95% CI) band of HR for patients aged <57 or >65 years is statistically significant. Top histogram shows distribution of age. (B) Forest plots of HR of cg14326354_PRODH 5% per decrement of methylation level in young and elderly LUAD patients, categorized based on boundary of 95% CI (BoCI) and 1956 United Nations standard. (C) Kaplan-Meier survival curves of low and high methylation groups (categorized by median value) among young and elderly LUAD patients defined using BoCI standard. P_{heterogeneity} was used to evaluate heterogeneity of HRs across age groups.