Research Paper Volume 12, Issue 11 pp 10427—10440

LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer

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Figure 6. PVT1 stimulates exosome secretion via palmitoylation of YKT6. (A) The level of palmitoylation of YKT6 in PVT1-overexpressing HS766T cells. (B) The level of palmitoylation of YKT6 in PVT1-overexpressing HS766T cells treated with Digitonine (control) or Triton X-100 (palmitoylation inhibitor). (C) The concentration of exosomes derived from PVT1-overexpressing HS766T cells treated with Digitonine (control) or Triton X-100 (palmitoylation inhibitor). *P < 0.05, data are expressed as the mean ± SD.