Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer

Feng Sun; Ke Wu; Zhixian Yao; Xingyu Mu; Zhong Zheng; Menghao Sun; Yong Wang; Zhihong Liu; Yiyong Zhu

doi:doi:10.18632/aging.103236

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Research Paper Volume 12, Issue 12 pp 11500—11516

Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer

Figure 1. Long noncoding RNA LINC00963 is increased in castration-resistant prostate cancer (CRPC) tissues. (A, B) Experimental approach to construct CRPC mouse models; TRAMP mouse (A) and ProbCre/Pten^fl/fl mouse (B). (C, D) Heat map of differential expression of long noncoding RNAs (lncRNAs) in cells isolated from normal prostate cancer (PCa) and CRPC mouse models (C, TRAMP mouse; D, ProbCre/Pten^fl/fl mouse). (E, F) The expression of the 10 most apparent up- and decreased lncRNAs were analyzed by RT-qPCR in CRPC tissues and compared to those in normal PCa tissues (E, TRAMP mouse; F, ProbCre/Pten^fl/fl mouse). (G) Intersection of differentially expressed lncRNAs according to sequencing assays. (H) Intersection of differentially expressed lncRNAs according to RT-qPCR. Mean ± SEM.