Figure 5.PLAGL2 accelerates CRC cell growth and migration. (A) WB indicated that downregulation of PLAGL2 could inhibit the expression of vimentin and N-cadherin and increase the expression of Zo-1 and E-cadherin. (B–C) CCK8 assays indicated that PLAGL2 promoted the proliferation of CRC cells. (D–E) Colony-formation assays indicated that PLAGL2 promoted the proliferation of CRC cells. (F) EDU assays indicated that PLAGL2 promoted the proliferation of CRC cells. (G–H) Transwell and wound-healing assays showed that PLAGL2 promoted the migration and invasion of CRC cells. The data are represented as the means±S.D. from at least three independent experiments. *p<0.05.
