Research Paper Volume 12, Issue 11 pp 10259—10274

Figure 5. Correlation analysis. (A) Significant negative correlation between age and hippocampal volume in HCs (r = -0.48, p < 0.0001). (B) Significant negative correlation between age and hippocampal volume in the LGG group (r = -0.28, p = 0.04). (C) There was no significant correlation between age and hippocampal volume in the HGG group (r = 0.02, p = 0.91). (D) Kaplan-Meier curves and log rank tests showed that a large hippocampal volume (≥ 6.92 cm³, n = 24) (mean OS: 21.5 months, 95% CI: 18.1-24.9 months) was associated with a shorter OS than a small hippocampal volume (< 6.92 cm³, n = 23) (mean OS: 27.7 months, 95% CI: 25.5-29.8 months) in high-grade glioma patients (n = 47, p = 0.007).