Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway

Kaishun Zhao; Ran Dong; Yanfang Yu; Chunlin Tu; Ying Li; YuJuan Cui; Lei Bao; Chunhua Ling

doi:doi:10.18632/aging.103180

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Research Paper Volume 12, Issue 10 pp 9125—9138

Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway

Figure 6. mRNA expression of CCR1 and downstream pathways in CSE-induced MH-S cells. (A, C–E) The RT-qPCR results show that once the CCR1 mRNA expression is inhibited, the CCR1/JAK/STAT3/NF-κB mRNA expression decreased significantly in CSE-induced MH-S cells, (B, F) but not the RANTES and TLR-4 mRNA expression.