miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A

Yong Xu; Wei Jiang; Lili Zhong; Hailun Li; Lin Bai; Xiaoling Chen; Yongtao Lin; Donghui Zheng

doi:doi:10.18632/aging.103160

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Research Paper Volume 12, Issue 11 pp 10235—10245

miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A

Figure 1. Identification of miR-195-5p in AKI. (A) Analysis of miR-195-5p in serum from healthy controls and patients with AKI. U6 served as a reference control. (B) Serum Cr levels in I/R rat models. (C) BUN levels in I/R rat models. (D) Representative micrographs of renal histologic findings. Scale bars = 20 μm. (E and F) Analysis of apoptosis using the TUNEL assay in renal tissues from AKI rats. (G) miR-195-5p expression in I/R rat models. (H) miR-195-5p expression in NRK-52E cells. Cells were exposed to hypoxia for 6 h. Eight rats were used in each group. Three independent experiments were performed. Error bars represent the mean ± SD of at least three independent experiments. *P < 0.05; **P < 0.01.