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Online ISSN: 1945-4589

Research Paper|Volume 12, Issue 9|pp. 8241–8260

Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

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Figure 3.LncRNA-MALAT1 transferred by exosomes caused rejuvenation against Dox. (A) LncRNA-MALAT1 mRNA in cardiomyocytes was examined by qRT-PCR. ^*P < 0.05 versus Control; ^▲P < 0.05 versus Dox. (B) Cell cycle distribution was analyzed. (C and D) p53 and p21 mRNA levels were analyzed by RT-qPCR. (E) Representative images of SA-β-gal staining. (F) Percentage of β-gal-positive cells. Each column represents the mean ± SD of three independent experiments. ^*P < 0.05 versus control; ^▲P < 0.05 versus Dox; ^□P < 0.05 versus Dox + exosome^{Hypoxia+siRNA-lncRNA-MALAT1}.