Figure 2 — Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model

Research Paper|Volume 12, Issue 9|pp. 8107–8119

Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model

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Figure 2.Effects of Nur77 on cytokines expression in MPP⁺-treated PC12 cells. (A) Nur77 increase NF-κB, TNF-α, IL-6 and MCP-1. (B–E) CSN-B and siNur77 treatment alone did not effect expression of NF-κB, TNF-α, IL-6 and MCP-1. MPP⁺ incubation pronouncedly increased level of NF-κB, TNF-α, IL-6 and MCP-1, while this elevation was abolished by CSN-B. (^***P < 0.001,^**P < 0.01 compared with control group; ^$$P < 0.01, ^$P < 0.05, NS = not significant. compared with MMP⁺ group; n=3, mean +/- SEM).