PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells

Yanping Liu; Huajun Bai; Fengfeng Guo; Phung N. Thai; Xiaoling Luo; Peng Zhang; Chunli Yang; Xueqin Feng; Dan Zhu; Jun Guo; Ping Liang; Zhice Xu; Huangtian Yang; Xiyuan Lu

doi:doi:10.18632/aging.103088

← Back

Research Paper Volume 12, Issue 8 pp 7411—7430

PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells

Figure 5. ZLN005-treated hESC-CMs exhibited more negative resting membrane potential compared with control. (A) Representative spontaneous action potential traces from control (red trace) and ZLN005-treated (black trace) hESC-CMs. (B–E) Action potential properties of control and ZLN005-treated hESC-CMs: the resting membrane potentials (B), peak amplitude (C), velocity of upstroke (D), action potential durations at 90% repolarization (APD90) (E) n=24-54 cells for each group.