c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

Liang Li; Chenju Yi; WenJie Xia; Bihui Huang; Shichao Chen; Junyan Zhong; Xiaoyi Fang; Liuming Yang; Hongwu Xin; Shiying Silvia Zheng; Beng H Chong; Yingyun Fu; Chun Chen; Mo Yang

doi:doi:10.18632/aging.103086

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Research Paper Volume 12, Issue 8 pp 7397—7410

c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

Figure 5. Brain morphology, histology, NSE staining of cortical neurons, and postural reflex test in sham-operated, vehicle-treated, and TPO-treated pups 3 weeks after surgery. Brain morphology and histology were examined at 3 weeks after surgery. Cortical neurons in the ipsilateral hemispheres were detected using NSE staining. (A) Normal external brain morphology and histology of sham-operated pups. (B) Brain morphology and histology of vehicle-treated pups. (C) Brain morphology and histology of TPO-treated pups. (D) The numbers of cortical neurons in the ipsilateral hemispheres of sham-operated, vehicle-treated, and TPO-treated pups, n = 3. (E) Postural reflex test scores in sham-operated (n = 12), vehicle-treated (n = 16), and TPO-treated pups (n = 16). * P < 0.05.