Figure 7 — HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 via miR-221-3p binding

Research Paper|Volume 12, Issue 9|pp. 7660–7678

HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 via miR-221-3p binding

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Figure 7.A mechanism map depicting the role of the HOTAIR/miR-221-3p/NPTX2 axis in PD. Inhibition of HOTAIR expression reduces autophagy of dopaminergic neurons through miR-221-3p-mediated down-regulation of NPTX2, thus retarding the onset and progression of PD.