Research Paper Volume 12, Issue 4 pp 3266—3286
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice
Figure 6. CD8+ T cells from elderly mice show a faster efflux of Ca2+. Exemplary combined protocol measurement of untouched (A) and stimulated (D) CD8+ T cells with a highlight on the Ca2+ plateau and efflux. Rate constants of untouched (B) and stimulated (E) CD8+ T cells from adult and elderly mice plotted against their respective Ca2+ plateaus. (C) Relative mRNA expressions of PMCA1 and 4 of untouched CD8+ T cells from adult (grey, n = 7) and elderly (red, n = 7) mice. (F) Relative mRNA expressions of PMCA1 and 4 of stimulated CD8+ T cells from adult (grey, n = 7) and elderly (red, n = 8) mice. Data obtained are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.