Figure 2. Variation in COX1 decreases mitochondrial mass with age. All measured mitochondrial indicators were normalized to the value of day 0 N2 worms. (A) Level variation of OCR with age. (B) Level variation of mtDNA with age. (C) Level variation of ROS with age. (D) ATP level variation with age. Data shown as the means ± SEM. Statistical analysis was performed by using two-tailed unequal variant Student’s t-test (* P-value < 0.05, ** P-value < 0.01).