Research Paper Volume 12, Issue 1 pp 912—930

Figure 7. Correlations of PRPF3 expression with immune infiltration level in HCC. (A) PRPF3 expression is significantly related to tumor purity and has significant positive correlations with infiltrating levels of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in LIHC. (B) PRPF3 CNV affects the infiltrating levels of CD8+ T cells, macrophages, neutrophils, and dendritic cells in HCC. (C) Multivariable hazards models were used to evaluate the impacts of PRPF3 expression on overall survival and disease-free survival in the presence of infiltrating levels of multiple immune cells. (D) Survival maps of top 20 PRPF3 positively and negatively correlated immune markers in LIHC, respectively. *, p < 0.05, **, p < 0.01, ***, p < 0.001.