Research Paper Volume 12, Issue 1 pp 690—706

Figure 4. Quantitative determination of Aβ₄₂ and apoptosis levels in brain tissue of control and AD model flies. Aβ₄₂ concentration and apoptotic DNA fragmentation representing the extent of apoptosis was examined with ELISA. Compared to the control group (left), which had low levels of Aβ₄₂ concentration (A, left) and cell apoptosis (B, left), the AD group had an increased concentration of Aβ (A, right) and apoptotic DNA fragments (B, right). The trends of Aβ₄₂ production (C) and neuronal apoptosis (D) in the WT (round dots) and AD (square dots) groups are displayed in the lower figures. Subsequent correlation analysis further indicated a potential relationship between AMP expression, Aβ₄₂ production, and neuronal apoptosis.