Research Paper Volume 11, Issue 24 pp 12733—12753

Figure 1. DEC1 deficient mice exhibit motor abnormalities. (A–C) Locomotion activity and motor coordination were analyzed by rotarod test (RT), beam walking test (BWT) and open-field test (OFT) in DEC1^+/+ and DEC1^-/- mice (n=15 in each group) at the age of 3, 6 and 12 months. (A) The latency to fall off the rotated rod in RT (Two-way AONVA, gene: F_(1,54)=17.767, p<0.001; age: F_(2,54)=6.041, p=0.004; interaction: F_(2,54)=0.297, p= 0.744). (B) Time to transverse the beam within 5 min in BWT (Two-way AONVA, gene: F_(1,40)=7.354, p=0.001; age: F_(2,40)=20.977, p<0.001; interaction: F_(2,40)=0.288, p= 0.751). (C) Total traveled distance (Two-way AONVA, gene: F_(1,49)=9.333, p=0.004; age: F_(2,49)=1.266, p=0.291; interaction: F_(2,49)=2.274, p= 0.114). The data are analyzed using t-test for the same age in two genotypes of mice and expressed as mean ± SD. *p<0.05, **p<0.01 vs the age-matched littermate DEC1^+/+ mice. ## p<0.01, ns p>0.05, comparisons are shown in the figure.