Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Hongrui Guo; Huan Liu; Zhijie Jian; Hengmin Cui; Jing Fang; Zhicai Zuo; Junliang Deng; Yinglun Li; Xun Wang; Ling Zhao; Yi Geng; Ping Ouyang; Weiming Lai; Zhengli Chen; Chao Huang

doi:doi:10.18632/aging.102570

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Research Paper Volume 11, Issue 23 pp 11659—11672

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Figure 7. Schematic diagram of the possible inflammatory response induced by NiCl₂. NiCl₂ triggers the transcription of pro-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-18, TNF-α and INF-β through the NF-κB, MAPKs, IRF3 signaling pathways in the BMDM. And NiCl₂ also can induce caspase-1 activation via NRLP3 inflammasome activation. Moreover, NiCl₂ induces apoptosis through mitochondrial ROS-mediated pathway, and also, NLRP3 inflammasome activation contributes to the apoptosis.