Figure 8.Role of circNF1-419 in regulated astrocyte and delay dementia. Circular RNA NF1-419 has autophagy enhancing activity by binding Dynamin-1 and AP2B1, delaying senile dementia by regulating aging markers (p21, p35/25, p16) and inflammatory factors (IL-6, IL-10, NF-κB), and by reducing the expression of AD marker proteins Tau, p-Tau, Aβ1-42, BACE1 and APOE.
