Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 24 pp 12002—12031
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice
Figure 6. CircNF1-419 delays senile dementia by enhancing autophagy in vivo. CircNF1-419 up-regulates the autophagy biomarkers including LC3A I, LC3A II, LC3B I and LC3B II (A), and improves the AD related regulators including p-Tau, p-Tau (202), p-Tau (396), Aβ A4, APOE, BACE1, TNF-α, NF-κB and p21 (B); histopathological (C) examination of hippocampus (Ca-b) and cortex (Cc-d); and immunostaining examination (D) of LC3A in hippocampus (De) and cortex (Df). All densitometric data of proteins expression using ImageJ are presented as the means±SD of 3 independent experiments. **p <0.01 vs. the model group by one-way ANOVA, followed by the Holm-Sidak test.