Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 24 pp 12002—12031
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice
Figure 3. Essential roles of circ-NF1-419 on proliferation, apoptosis, cell cycle and autophagy test. Influence on astrocyte proliferation (A), apoptosis (B), and cell cycle (C); Western blot analysis (D) showed the levels of Atg12, LC3A, LC3B in over-expressing circNF1-419-transfected rat astrocytes; (E) Transmission electron microscopic imaging showing autolysosomes (arrows) and autophagosomes with double-membraned autophagic vacuoles (arrowheads) in over-expression circNF1-419-transfected rat astrocyte. Scale bar: 5μm and 2μm. Data are presented as the means±SD of 3 independent experiments. **p <0.01 vs. the model group by one-way ANOVA, followed by the Holm-Sidak test.