Research Paper Volume 11, Issue 23 pp 11186—11201

Figure 7. Schematics illustrating the effects of active compounds on iron metabolisms in neurons. (A) in normal cells, iron are transported into cells by TF, TfR1, or the DMT1 with/without IRE on the membrane. Some iron bind to FN (Fth or Ftl1) and then are transported out of cells by FPN1, HP, and CP. (B) In abnormal iron metabolism cells, increases in TF, TFR and DMT1 with/without IRE, which transport more iron into cells, and decreases in CP and HP, which transport less iron out of the cells, results an increase in intracellular iron concentration. (C) Application of active compounds reduces TF, TFR and DMT1 with/without IRE and increase CP, HP and FPN1 to recover intracellular iron concentration.