Research Paper Volume 11, Issue 21 pp 9875—9892

Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1

class="figure-viewer-img"

Figure 8. Schematic model of how TG NPs ameliorate CKD progression. TG NPs could induce the UPR pathway in kidney cells. Furthermore, TG NPs protected kidney cells against oxidative stress-induced cell death through the activation of Nrf2 and FoxO1. In addition, TG NPs induced autophagy that may inhibit CKD progression.