Research Paper Volume 11, Issue 21 pp 9875—9892

Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1

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Figure 7. TG NPs and KIM-1-TG NPs protect against tubulointerstitial injury in mice with CKD induced by adenine. (A) Representative photographs of histological changes showing sections of renal tissue from mice after H&E staining. Immunohistochemical analysis of the protein expression of LC3 (B), FoxO1 (C) and Nrf2 (D) in the sections of renal tissue. The percentage of LC3-positive cells was determined using HistoQuest software (TissueGnostics). (A, B) Scale bar = 50 μm. (C, D) Scale bar = 25 μm.