Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both <i>in vivo</i> and <i>in vitro</i> models of Parkinson's disease

Chao Guo; Junrong Zhu; Jingwen Wang; Jialin Duan; Shanbo Ma; Ying Yin; Wei Quan; Wei Zhang; Yue Guan; Yi Ding; Aidong Wen; Yingdong Zhang

doi:doi:10.18632/aging.102394

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Research Paper Volume 11, Issue 21 pp 9424—9441

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Figure 5. PCA reduced cytotoxicity and apoptosis in MPP⁺-incubated SH-SY5Y cells. (A) Histogram showing cell viability at different dosages of PCA. (B) Quantification analysis of apoptosis rate. (C) Representative pictures of flow cytometry for apoptosis in each group. Data were presented as mean ± S.D., n = 6; ^**P< 0.01vs. control group; ^#P< 0.05 vs. MPP⁺group.