Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both <i>in vivo</i> and <i>in vitro</i> models of Parkinson's disease

Chao Guo; Junrong Zhu; Jingwen Wang; Jialin Duan; Shanbo Ma; Ying Yin; Wei Quan; Wei Zhang; Yue Guan; Yi Ding; Aidong Wen; Yingdong Zhang

doi:doi:10.18632/aging.102394

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Research Paper Volume 11, Issue 21 pp 9424—9441

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Figure 11. Overexpression of PLK2 strengthened the protection of PCA. (A) The bands of PLK2, p-GSK3β and nucleus Nrf2 after transfected with pcDNA3.1-PLK2 vector (pcDNA-PLK2, pc-PLK2) and the empty vector control (pcDNA-Con, pc-Con) for 48 h. (B–D) The quantification of PLK2, p-GSK3β/ GSK3β and nuclear Nrf2 levels in each group. (E) The cell viability in each group. Data were presented as mean ± S.D., n = 6; ^*P < 0.05 vs. control group; ^#P< 0.05 vs. MPP⁺group; ^&P < 0.05 vs. pc-Con group.