Research Paper Volume 11, Issue 21 pp 9424—9441
Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease
Figure 10. PLK2 knockdown attenuated the protection of PCA. (A) Representative western blot bands showing the expressions of PLK2, p-GSK3β and nucleus (Nu) Nrf2 when SH-SY5Y cells were transfected with PLK2 siRNA (si-PLK2) and Non-targeting siRNA (si-Non) for 72h. (B–D) The quantification of PLK2, p-GSK3β and nucleus Nrf2 levels in si-PLK2 group and the others groups. (E) Cell viability was measured by MTT assay. Data were presented as mean ± S.D., n = 6; *P < 0.05 vs. control group; #P< 0.05 vs. MPP+group; &P < 0.05 vs. si-Non group.