Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Tingting Xu; Xiangting Ge; Chun Lu; Wei Dai; Hongjin Chen; Zhongxiang Xiao; Liqin Wu; Guang Liang; Songmin Ying; Yali Zhang; Yuanrong Dai

doi:doi:10.18632/aging.102371

← Back

Research Paper Volume 11, Issue 21 pp 9310—9327

Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Figure 5. Baicalein attenuates OVA-induced mucus production. Goblet cell hyperplasia and mucin gene expression were used to measure mucus production in mice. (A) PAS staining was performed to identify goblet cell hyperplasia in the airway epithelium. Images are shown at 200× magnification with a scale bar representing 100 μm. (B) Quantification of mucus-producing goblet cells in lung tissues detected by PAS staining. The mRNA levels of the mucus-related genes MUC5AC (C) and MUC5B (D) were quantified by RT-qPCR and normalized to those of β-actin (n = 6 mice per group; ^##P < 0.01 compared with the control group; *P < 0.05 compared with OVA/Vehicle group, **P < 0.01 compared with the OVA/Vehicle group).