Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Tingting Xu; Xiangting Ge; Chun Lu; Wei Dai; Hongjin Chen; Zhongxiang Xiao; Liqin Wu; Guang Liang; Songmin Ying; Yali Zhang; Yuanrong Dai

doi:doi:10.18632/aging.102371

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Research Paper Volume 11, Issue 21 pp 9310—9327

Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Figure 1. Baicalein relieves OVA-induced AHR in mice. (A) The construction of a model of OVA-induced allergic airway inflammation. Mice were sensitized by OVA/Al(OH)₃ on day 0 and day 14, while from days 25 to 31, the mice were exposed to 1% OVA aerosol for 7 consecutive days. (B) Airway responsiveness was assessed as the mean response of mechanically ventilated mice to increased doses of Mch (mean ± SEM; n = 6 per group; ^**P < 0.01 compared with the control group).