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Research Paper Volume 11, Issue 20 pp 8969—8981

Expression and significance of miR - 20b in retinal photoreceptor cells exposed to PCB1254

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Figure 7. Overexpression of FGF2 and GRB2 attenuated the adverse effects of miRNA-20b on 661W cells. (A) mRNA expression levels of FGF2 and GRB2 after transfection with PEX-2-FGF2 or PEX-2-GRB2 and PEX-2 as controls. The results showed that the expression of mRNA increased significantly in the overexpression group. (B) The miRNA-20b mimics co-transfected with PEX-2-FGF2 or PEX-2-GRB2 significantly increased the proliferation of cells compared to the miRNA-20b mimic group. (C–D) Groups co-transfected with miRNA-20b mimics and PEX-2-FGF2 or PEX-2-GRB2 groups reduced the effect of the miRNA-20b mimics on apoptosis. (*: P <0.05).