Figure 6.Summary of our study. CACNA1S, CACNB1, and CACNG1 are significantly increased in the NGS study and immunohistochemistry in the lamina propria of aging vocal folds. The synthesis of collagen I and III of hVFFs with si-CACNA1S are reduced significantly. When verapamil is treated in hVFFs, the expression of CACNA1S and the synthesis of collagen I and III are decreased and the expression of MMP-1 and 8 are increased. Voltage gaited calcium channel, especially CACNA1S, has promising potential as a novel therapeutic target for remodeling ECM of lamina propria.
