Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 18 pp 7570—7586
Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation
Figure 1. LIMK1, RhoA and ROCK1 mRNA expression was inhibited by up-regulation of miR-93. (A) miR-93, LIMK1, RhoA and ROCK1 expression levels in myocardial tissues of each group by RT-qPCR; (B) Protein bands of LIMK1, RhoA and ROCK1 in myocardial tissues; (C) LIMK1, RhoA and ROCK1 protein expression in myocardial tissues of all group by western blot assay; * P < 0.05 vs. the sham group; #P < 0.05 vs. the mimics-NC group; & P < 0.05 vs. the siRNA-NC group; $ P < 0.05 vs. the miR-93 mimics + OE-NC group; N = 8; the data is expressed as mean ± standard deviation; the data are analyzed by using one-way ANOVA, and LSD-t method was used for pairwise comparison after ANOVA.