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Research Paper Volume 11, Issue 20 pp 8792—8809
Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD
Figure 1. LncRNA MALAT1 is up-regulated in hypertensive rats. (A) MAP and HR of SD and SHRs; (B) LVW and LVW/BW ratio in SD and SHRs; (C) images of myocardial tissues observed by Masson staining (scale bar = 50 μm); (D) images of myocardial tissues detected by HE staining (scale bar = 25 μm); (E) pathological changes of thoracic aortic vascular tissues in SD rats and SHRs observed using HE staining (× 40); (F) collagen deposition in thoracic aortic vascular tissues in SD rats and SHRs observed using Masson staining (× 400); (G) the expression of fibronectin and collagen I in vascular tissues of SD rats and SHRs, tested by Western blot analysis; (H–I) the expression of lncRNA MALAT1 in myocardial tissues (H) and thoracic aortic vascular tissues (I) in SD rats and SHRs, tested by RT-qPCR; *, p < 0.05 vs. the SD rats; measurement data were expressed by means ± standard deviation and analyzed by unpaired t-test; SD rats = 30, SHRs = 10.