Figure 5. Time-dependent ROC curves to compare the prognostic accuracy of the four-miRNA signature with clinicopathological risk factors and single miRNAs in all the 791 patients. (A, B) Comparisons of the prognostic accuracy by the four-miRNA-based signature, age, preoperative CEA level, clinical stages, and combined clinicopathological prognostic factors and miRNA signature. (C, D) Comparisons of the prognostic accuracy by the four-miRNA-based signature, and miR-210, miR-375, miR-26a, miR-197. P values were from the comparisons of the AUC of the miRNA signature versus the AUC of other factors.