Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis

Peipei Chen; Yuexin Chen; Wei Wu; Lianfeng Chen; Xufei Yang; Shuyang Zhang

doi:doi:10.18632/aging.102200

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Research Paper Volume 11, Issue 16 pp 6469—6489

Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis

Figure 4. Common hub genes and pathways in differentiating plaque sets and poor prognosis sets. A five-set Venn diagram showing a combination of all differentially expressed genes of GO processes and KEGG pathways in differentiating plaque sets and poor prognosis sets. A total of 4 common genes were identified. Fold change and P value of the 4 common genes in differentiating plaque sets and poor prognosis sets. They are all upregulated genes. Four-way Venn diagram of GO processes and KEGG pathways identified in differentiating plaque sets and poor prognosis sets. A total of 4 GO processes and 9 KEGG pathways were identified in common between the training set and differentiating plaque sets. Details of the common pathways from Venn diagram analysis. FC₁: fold change in differentiating plaque sets; FC₂: fold change in poor prognosis sets.