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Research Paper Volume 11, Issue 16 pp 6312—6335

Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma

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Figure 2. Direct and indirect effects of DNA methylation on lung adenocarcinoma survival mediated through gene expression in casual mediation analysis. DNA methylation risk score (MRS) and gene expression risk score (GRS) were calculated by linear combination with a weighted ln(HRadjusted) of identified probes.