TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Chuanfei Li; Di Zhou; Hao Hong; Shuangyan Yang; Li Zhang; Shiying Li; Peng Hu; Hong Ren; Zhechuan Mei; Hui Tang

doi:doi:10.18632/aging.102140

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Research Paper Volume 11, Issue 15 pp 5593—5612

TGFβ1- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Figure 10. Model for the TGFβ1-miR-140-5p axis in which up-regulation of FEN1 promotes HCC cells invasion and migration via accelerating the EMT process. EMT, epithelial-mesenchymal transition.