Research Paper Volume 11, Issue 15 pp 5368—5388
Downregulation of microRNA-218 is cardioprotective against cardiac fibrosis and cardiac function impairment in myocardial infarction by binding to MITF
Figure 1. MiR-218 is highly expressed in cardiac tissues and downregulated miR-218 improved cardiac function in MI rats. (A) miR-218 expression in cardiac tissues of rats in the sham group and MI group detected by RT-qPCR, n = 3; (B) miR-218 expression in cardiac tissues of MI rats of the MI group, the MI + inhibitors NC group and the MI + miR-218 inhibitors group, n = 3; (C) the LVEF and LVFS of rats detected by ultrasonic cardiogram, n = 12; (D) the LVSP, LVEDP, +dp/dt max and -dp/dt max of rats detected by hemodynamic monitoring, n = 12; *versus the sham group, P < 0.05; #versus the MI group, P < 0.05; Data were analyzed by t test or one-way ANOVA. Pairwise comparison after ANOVA was performed by LSD-t. MI, myocardial infarction; miR-218, microRNA-218; LVEF, left ventricular ejection fraction; LVFS, left ventricular fraction shortening; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end diastolic pressure; RT-qPCR, reverse transcription quantitative polymerase chain reaction.