Figure 4 — Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

Research Paper|Volume 11, Issue 12|pp. 4107–4124

Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

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Figure 4.GSPs eliminated STZ-induced neuronal loss in the cortex and CA1, CA3 and DG of hippocampus. Representative images of immunofluorescence staining assay of NeuN in the cortex (A), hippocampal CA1 (C), CA3 (E) and dentate gyrus (G) areas. Quantification of NeuN-positive cells in the cortex (B), hippocampal CA1 (D), CA3 (F) and dentate gyrus (H) areas. ^*P < 0.05, ^**P < 0.01 vs Sham; ^#P < 0.05, ^#P < 0.01 vs STZ, n=4-6.