Research Paper Volume 11, Issue 11 pp 3851—3863

Figure 4. The effect of TRF on markers of systemic aging in rats exposed to ALF or TRF for 18 months and continued on ALF for additional 3 months. (A) Plasma levels of IGF-1 were decreased in TRF group (p-value <0.05). (B and C) BDNF levels in the hippocampus and plasma; differences were statistically significant in the hippocampus (*p-value <0.05). (D) Plasma triglycerides, LDL and HDL levels in rats after 1 or 2 years on ALF regimen. A significant increase in all parameters was seen at 2 years (**p <0.01; ***p <0.001). (E) Plasma lipids profile in rats exposed to ALF or TRF for 18 months and continued on ALF for additional 3 months. Rats receiving TRF had lower levels of triglycerides, LDL and HDL (*p-value <0.05; **p-value <0.01).