Research Paper Volume 11, Issue 8 pp 2202—2216
Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
Figure 8. Combining low-dose Azithromycin and Doxycycline with Vitamin C (DAV), dramatically inhibits metabolism: Bar graphs. Note that the rate of oxidative mitochondrial metabolism was reduced by >50% and ATP levels were drastically reduced by >95%, as assessed using the Seahorse XFe96 analyzer. This resulted in significant reductions in both basal and maximal respiration. Note also that glycolysis was increased, while glycolytic reserve was decreased by the triple combination. ***p < 0.001; ****p < 0.0001.