Figure 3. Plasma ceramide and estradiol concentrations in men and women. (A) Plasma ceramide levels in, left, pre-menopausal women (20-54 years, n = 44) and age-matched men (19-54 years, n = 48) and, right, post-menopausal women (47-78 years, n = 40) and age-matched men (55-80 years, n = 32). (B) Plasma estradiol levels in, left, pre-menopausal women (20-54 years, n = 44) and age-matched men (19-54 years, n = 48) and, right, post-menopausal women (47-78 years, n = 40) and age-matched men (55-80 years, n = 32). *p < .05, **p < .01, ***p < .001; 2-way ANOVA followed by Bonferroni post-hoc test (women 20-54 years versus men 19-54 years). # p < .05, ## p < .01, ### p < .001; 2-way ANOVA followed by Bonferroni post-hoc test (women 20-54 years versus women 47-78 years).