Review Volume 10, Issue 11 pp 3590—3609

Figure 4. Three dimensional spatial changes in the genome during senescence. The 3D arrangement of the genome suffers significant changes in senescence; for example there is evidence of compartment switching, TAD fusing, TAD separation and TAD shifting. Some of these changes are also triggered by decline in chromatin architectural proteins such as HMGB2, a consequence of which is SICC formation. However, in general, TAD structure is maintained.