Research Paper Volume 10, Issue 10 pp 2585—2605

H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions

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Figure 11. Schematic illustration of protein levels in DNA lesions in wild-type and Suv39h1/h2 dn mouse embryonic fibroblasts. Colored dots illustrate the levels of selected proteins at UVA-irradiated chromatin. The illustration demonstrates the appearance of the following proteins at DNA lesions: HP1β (pink circles), H3K9me3 (orange circles), H3K9ac (dark green circles), H4K20me3 (red circles), γH2AX (pale green circles), and 53BP1 (white circles). The selected micro-irradiated ROI is shown by a white rectangle. The figure represents an illustration of our results.