CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesenchymal transition via PI3K/AKT signaling

Zhao Liu; Mi Chen; Lin-Ka Xie; Ting Liu; Zhen-Wei Zou; Yong Li; Peng Chen; Xin Peng; Charlie Ma; Wen-Jie Zhang; Pin-Dong Li

doi:doi:10.18632/aging.101571

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Research Paper Volume 10, Issue 10 pp 2570—2584

CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesenchymal transition via PI3K/AKT signaling

Figure 4. CLCA4 inhibits cell migration and invasion in HCC cell lines. (A, B) CLCA4 silenced in Hep-3B cells and promoted cell migration and invasion. (C, D) CLCA4 up-regulated in SMMC-7721 cells and inhibited cell migration and invasion. (E) Lung H&E staining of nude mice inoculated Hep-3B and SMMC-7721 transfected cells via tail vein. The number of lung tumor nodules in each group were also calculated, * P < 0.05.