p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model

Nataliya G. Kolosova; Oyuna S. Kozhevnikova; Darya V. Telegina; Anzhela Zh. Fursova; Natalia A. Stefanova; Natalia A. Muraleva; Franco Venanzi; Michael Y. Sherman; Sergey I. Kolesnikov; Albert A. Sufianov; Vladimir L. Gabai; Alexander M. Shneider

doi:doi:10.18632/aging.101537

← Back

Research Paper Volume 10, Issue 8 pp 2136—2147

p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model

Figure 6. p62 (SQSTM1) as a mediator of several pathways. Anti-inflammatory effect of p62 can be mediated via inhibition of NF-kB pathway as well as antioxidant response and clearance of damaged proteins/organelles (e.g., mitochondria) [25–28].