Research Paper Volume 10, Issue 2 pp 229—240
Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)
Figure 11. Overall Work-Flow: Identifying mitochondrial inhibitors to target CSC propagation. Here, we selected TPP-related compounds as the starting point for screening, because this ensures that all the compounds tested are targeted to mitochondria. Remarkably, we show that this strategy yields mitochondrial inhibitors of CSCs that are non-toxic in normal human fibroblasts, thereby effectively limiting drug toxicity.