Editorial Volume 10, Issue 1 pp 17—18
Stem cell depletion by inflammation-associated miR-155
Figure 1. Schematic representation of the miR-155-mediated stem cell deterioration.
In the inflammatory condition, upregulated miR-155 activates stem cell differentiation, but expression of antioxidant-related genes is suppressed by miR-155. Thus, it is thought that excessive inflammation and miR-155 expression could be a risk for stem cell depletion and disturbance of tissue integrity.